Description

2-Hydroxymethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a versatile chiral building block and protected amino alcohol derivative of significant value in advanced organic synthesis. Its primary importance lies in its role as a key intermediate for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable intermediates for API synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, neurological agents, and other bioactive molecules.
• Peptidomimetics & Scaffold Development: Used to introduce the pyrrolidine scaffold with a protected hydroxymethyl group, enabling the creation of novel peptidomimetics and constrained analogs in drug discovery.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for asymmetric transformations, leveraging the stereogenic center of the pyrrolidine ring.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that incorporate nitrogen-containing heterocycles.
• Ligand & Catalyst Preparation: Useful for preparing chiral ligands for metal-catalyzed reactions or as a precursor for organocatalysts.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for custom synthesis projects and scale-up manufacturing under GMP or non-GMP conditions.

Basic Information

Product Name	2-Hydroxymethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	170491-63-1
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	1-Boc-2-(hydroxymethyl)pyrrolidine; (2-Hydroxymethyl-1-pyrrolidinyl)carboxylic acid tert-butyl ester; tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate; 1-N-Boc-2-hydroxymethylpyrrolidine; 2-(Hydroxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 2-(hydroxymethyl)-1-pyrrolidinecarboxylate; Boc-2-pyrrolidinemethanol; 2-Pyrrolidinemethanol, 1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 2-Hydroxymethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity assessment, to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.