Description

3-Amino-n-[(1,1-Dimethylethoxy)Carbonyl]- L-Phenylalanine is a protected amino acid derivative, specifically a Boc-protected variant of 3-amino-L-phenylalanine, which serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, chiral intermediates for the construction of complex peptides and peptidomimetics. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues.
• Protease Inhibitor Development: Serves as a core structure for designing inhibitors targeting specific proteolytic enzymes.
• Bioconjugation & Probe Synthesis: Facilitates the creation of labeled peptides and molecular probes for biochemical and diagnostic applications.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Chemical Biology: Used to synthesize peptide-based tools for studying protein-protein interactions and cellular signaling pathways.

Basic Information

Product Name	3-Amino-n-[(1,1-Dimethylethoxy)Carbonyl]- L-Phenylalanine
CAS No.	170157-55-8
Molecular Formula	C₁₄H₂₀N₂O₄
Molecular Weight	280.32 g/mol
Synonyms	Boc-3-amino-L-phenylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(3-aminophenyl)propanoic acid; 3-Amino-L-phenylalanine, N-Boc-; N-Boc-3-amino-L-phenylalanine; tert-Butyloxycarbonyl-3-amino-L-phenylalanine; Boc-A3ph-OH; 3-Amino-L-Phe(Boc); L-Phenylalanine, 3-amino-N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 3-Amino-n-[(1,1-Dimethylethoxy)Carbonyl]- L-Phenylalanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with major pharmacopeial standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.