Description

Ethyl n-Boc-3-oxopyrrolidine-2-carboxylate is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for the efficient and stereoselective construction of complex molecular architectures, particularly in the pharmaceutical sector. It is primarily sought after by research chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of proline-based drug candidates and complex heterocycles.
• Peptidomimetics Research: Used in the design and construction of peptide analogs to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• API Development: Integral to the research and process development of new Active Pharmaceutical Ingredients (APIs), especially those containing pyrrolidine or related scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Industrial R&D: Utilized in discovery chemistry for building diverse compound libraries and exploring new chemical entities.

Basic Information

Product Name	Ethyl n-Boc-3-oxopyrrolidine-2-carboxylate
CAS No.	170123-25-8
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	Ethyl 1-(tert-Butoxycarbonyl)-3-oxopyrrolidine-2-carboxylate; 1-Boc-3-oxopyrrolidine-2-carboxylic Acid Ethyl Ester; 2-Carbethoxy-1-Boc-3-pyrrolidinone; 1-N-Boc-3-oxopyrrolidine-2-carboxylic Acid Ethyl Ester; Ethyl 1-Boc-3-oxo-2-pyrrolidinecarboxylate; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-oxopyrrolidine-2-carboxylic Acid Ethyl Ester (if applicable to specific enantiomer); Boc-3-oxoproline ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl n-Boc-3-oxopyrrolidine-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess (if applicable), and identity confirmation by IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (if applicable)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.