Description

L-Phenylalanine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (R)- (9Ci) is a sophisticated, optically active amino acid derivative, specifically engineered as a key chiral building block for advanced organic synthesis. Its value lies in providing a protected phenylalanine moiety with a tert-butyloxycarbonyl (Boc) protecting group on the α-amino function, offering precise stereochemical control for researchers and process chemists. This compound is essential for the development of novel pharmaceuticals, bioactive peptides, and complex organic molecules where high purity and defined stereochemistry are non-negotiable. CAS number 169453-30-9.

Application

• Pharmaceutical Intermediates: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to construct complex peptide sequences with high fidelity.
• Proteomics & Biochemical Research: Serves as a specialized reagent in biochemical studies, enzyme substrate design, and the synthesis of labeled compounds for metabolic pathway analysis.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric synthesis to introduce the (R)-configured phenylalanine backbone into target molecules.
• Combinatorial Chemistry: Utilized in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Potential application in the synthesis of chiral active ingredients for crop protection agents.

Basic Information

Product Name	L-Phenylalanine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (R)- (9Ci)
CAS No.	169453-30-9
Molecular Formula	C17H26N2O3
Molecular Weight	306.40 g/mol
Synonyms	Boc-D-Phenylalanine methyl ester; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate; D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-D-Phe-OMe; N-Boc-D-phenylalanine methyl ester; Methyl N-Boc-D-phenylalaninate; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our L-Phenylalanine derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and fine chemical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.