Description

L-Histidine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci) is a specialized, high-purity histidine derivative designed for advanced research and pharmaceutical development. This compound serves as a critical chiral building block and intermediate in the synthesis of complex peptides and active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise molecular control for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development and study of protease inhibitors due to its modified histidine structure.
• Bioconjugation & Labeling: Serves as a reactive handle for bioconjugation chemistry, enabling the attachment of probes, drugs, or polymers.
• Medicinal Chemistry & Drug Discovery: Employed as a building block in structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to investigate biological pathways.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the custom synthesis of complex organic molecules.

Basic Information

Product Name	L-Histidine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci)
CAS No.	169453-11-6
Molecular Formula	C15H26N4O3
Molecular Weight	310.40 g/mol
Synonyms	(S)-N-[1-[[(1,1-Dimethylethyl)amino]carbonyl]-2-methylpropyl]-L-histidine methyl ester; Boc-L-tert-Leu-L-His-OMe; tert-Butoxycarbonyl-L-tert-leucyl-L-histidine methyl ester; Boc-L-tert-leucyl-L-histidine methyl ester; L-Histidine, N-[1-[[(1,1-dimethylethyl)amino]carbonyl]-2-methylpropyl]-, methyl ester, (S)-; Histidine derivative CAS 169453-11-6
EINECS	Contact for details

Quality Control

Our L-Histidine derivative is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.