Description

Glycine, n-[n-[1-(Methoxycarbonyl)-2-Methylpropyl]-L-Valyl]-, Methyl Ester, (S)- (9Ci) is a specialized, optically active peptide derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its structural complexity and defined stereochemistry. It is primarily required by pharmaceutical research and development organizations for the synthesis of novel active pharmaceutical ingredients (APIs), complex peptides, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based therapeutics and other complex drug molecules.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to construct specific sequences.
• Bioconjugation Chemistry: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, protein-protein interactions, and as a probe in biochemical assays.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable synthesis of target compounds in process R&D.
• Academic Research: Serves as a reagent in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Glycine, n-[n-[1-(Methoxycarbonyl)-2-Methylpropyl]-L-Valyl]-, Methyl Ester, (S)- (9Ci)
CAS No.	169453-03-6
Molecular Formula	C15H26N2O5
Molecular Weight	314.38 g/mol
Synonyms	(S)-Methyl N-[(2S)-2-[[(2S)-2-Isopropyl-3-methoxy-3-oxopropyl]amino]-4-methyl-1-oxopentan-2-yl]glycinate; N-[(S)-1-[(S)-1-Carboxy-2-methylpropylcarbamoyl]-2-methylpropyl]glycine Methyl Ester; (S)-Glycine, N-[N-[1-(methoxycarbonyl)-2-methylpropyl]-L-valyl]-, methyl ester; Boc-Val-Gly-OMe derivative (specific protected form); L-Valyl-glycine methyl ester derivative; Peptide building block 169453-03-6; Chiral dipeptide mimetic ester.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.