Description

Desloratadine Pyridine n-Oxide is a key pharmaceutical intermediate in the synthesis of the non-sedating antihistamine Desloratadine. This compound matters for its critical role in ensuring the purity, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily needed by manufacturers in the pharmaceutical and fine chemical industries engaged in advanced antihistamine production and research & development.

Application

• Primary Intermediate in the commercial synthesis of Desloratadine API.
• Process Development for optimizing manufacturing routes and scaling up production.
• Quality Control Reference Standard for analytical method development and validation.
• Research & Development of novel antihistamine derivatives and related therapeutic agents.
• GMP Manufacturing of pharmaceutical products requiring high-purity chemical building blocks.

Basic Information

Product Name	Desloratadine Pyridine n-Oxide
CAS No.	169253-26-3
Molecular Formula	C19H19ClN2O2
Molecular Weight	342.82 g/mol
Synonyms	8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine N-Oxide; Desloratadine N-Oxide; Desloratadine Pyridine Oxide; Desloratadine Related Compound; 8-Chloro-11-(4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 1-Oxide
EINECS	Contact for details

Quality Control

Our Desloratadine Pyridine n-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The material should be handled as moisture-sensitive.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.