Description

Fmoc-L-4-Fluorophe CAS NO 169243-86-1 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the 4-fluorophenylalanine residue into peptide chains, enabling the study of structure-activity relationships and the development of novel bioactive peptides. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on peptide-based drug discovery, diagnostic agents, and biochemical research.

Application

• Peptide Drug Discovery & Development: A key intermediate for synthesizing peptide analogs and libraries to screen for new therapeutic candidates.
• Biochemical Research: Used to incorporate fluorinated amino acids into model peptides to study protein folding, stability, and fluorophore labeling.
• Pharmaceutical Intermediates: Serves as a crucial raw material in the multi-step synthesis of complex peptide active pharmaceutical ingredients (APIs).
• Proteomics & Molecular Biology: Employed in the synthesis of specialized peptide probes, antigens, and enzyme substrates.
• Material Science: Potential use in creating novel fluorinated biomaterials and peptidomimetics with unique properties.

Basic Information

Product Name	Fmoc-L-4-Fluorophe CAS NO 169243-86-1
CAS No.	169243-86-1
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-4-fluoro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-L-phenylalanine; Fmoc-Phe(4-F)-OH; Fmoc-L-4-Fluorophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-fluorophenyl)propanoic acid; N-α-Fmoc-4-fluoro-L-phenylalanine; Fmoc-4-F-L-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-Fluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC & IR)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.