Description

1-Bromo-2-Fluoro-4-(Trifluoromethoxy)Benzene is a high-value, multi-functional halogenated aromatic building block. Its unique structure, incorporating bromine, fluorine, and a trifluoromethoxy group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require precise molecular scaffolds for advanced synthesis. Its primary utility lies in facilitating complex cross-coupling reactions and serving as a precursor for active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to efficacy and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine substituent.
• Fluorinated Compound Library: Integral for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organofluorine chemistry and novel synthetic methodologies.

Basic Information

Item	Details
Product Name	1-Bromo-2-Fluoro-4-(Trifluoromethoxy)Benzene
CAS No.	168971-68-4
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	2-Fluoro-4-(trifluoromethoxy)bromobenzene; 4-Bromo-3-fluoro(trifluoromethoxy)benzene; 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene; Benzene, 1-bromo-2-fluoro-4-(trifluoromethoxy)-; 3-Fluoro-4-bromo(trifluoromethoxy)benzene; 2-Fluoro-1-bromo-4-(trifluoromethoxy)benzene; 4-(Trifluoromethoxy)-2-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-2-Fluoro-4-(Trifluoromethoxy)Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and compliance with REACH regulations ensures a reliable supply for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.