Description

Benzyl (S)-(4-Hydroxybutan-2-Yl)Carbamate CAS NO 168827-91-6 is a chiral carbamate derivative of significant interest in advanced organic synthesis. This compound serves as a crucial protected intermediate for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by process chemists and R&D scientists in the fine chemical, pharmaceutical, and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value chiral targets.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetic Synthesis: Used in the preparation of peptide analogs and mimetics where the hydroxybutyl side chain and carbamate protection are required.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective reactions to introduce specific stereocenters into target molecules.
• Protecting Group Strategy: The benzyloxycarbonyl (Cbz) group acts as a protective group for amines, which can be selectively removed under controlled conditions.
• Agrochemical Research: Intermediate in the development of chiral pesticides and herbicides where specific stereochemistry is essential for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in transition metal catalysis and organocatalysis.

Basic Information

Product Name	Benzyl (S)-(4-Hydroxybutan-2-Yl)Carbamate
CAS No.	168827-91-6
Molecular Formula	C12H17NO3
Molecular Weight	223.27 g/mol
Synonyms	(S)-Benzyl (4-hydroxybutan-2-yl)carbamate; (S)-2-(Benzyloxycarbonylamino)butan-4-ol; (S)-N-Cbz-2-Aminobutan-4-ol; Carbamic acid, N-[(1S)-4-hydroxy-2-butyl]-, phenylmethyl ester; (S)-4-Hydroxy-2-(N-Cbz-amino)butane; Benzyl (S)-2-(Cbz-amino)-4-hydroxybutyl ether (common misnomer); (S)-N-(Benzyloxycarbonyl)-2-aminobutan-4-ol
EINECS	Contact for details

Quality Control

Our Benzyl (S)-(4-Hydroxybutan-2-Yl)Carbamate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom purity grades and specifications tailored to your synthetic pathway.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.