Description

(R)-Nipecotamide is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its defined stereochemistry makes it a critical building block for the development of enantiomerically pure active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of novel therapeutics, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, including GABA analogs and other neuroactive compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and production of new chemical entities (NCEs).
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Biochemical Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and target validation.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Fine Chemical Synthesis: Used in the production of specialized agrochemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	(R)-Nipecotamide
CAS No.	168749-30-2
Molecular Formula	C6H12N2O
Molecular Weight	128.17 g/mol
Synonyms	(R)-3-Piperidinecarboxamide; (R)-3-Aminocarbonylpiperidine; (R)-Nipecotic acid amide; (R)-Piperidine-3-carboxamide; (3R)-Piperidine-3-carboxamide; (R)-(-)-Nipecotamide; (R)-3-Carbamoylpiperidine; (R)-3-Piperidinecarboxylic acid amide
EINECS	Contact for details

Quality Control

Our (R)-Nipecotamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and standard impurity profiles, to meet the stringent requirements of pharmaceutical development. A Certificate of Analysis (COA) detailing specifications such as assay, chiral purity by HPLC, and residual solvent levels is supplied with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.