Description

7-Hydroxy-2H-1-Benzopyran-2-One Glucuronide Sodium Salt is a high-purity, conjugated metabolite of umbelliferone (7-hydroxycoumarin). This compound is of significant value as a key reference standard and biochemical intermediate in pharmaceutical research and development. It is primarily required by analytical laboratories, research institutions, and manufacturers in the life sciences sector for metabolite identification, pharmacokinetic studies, and the development of advanced diagnostic assays.

Application

• Pharmaceutical Reference Standard: Critical for the quantification and validation of umbelliferone metabolites in bioanalytical methods (HPLC, LC-MS/MS) during drug metabolism and pharmacokinetic (DMPK) studies.
• Biochemical Research: Used as a substrate or intermediate in enzymatic studies, particularly those investigating glucuronidation pathways and phase II drug metabolism.
• Diagnostic Reagent Development: Serves as a key component in developing fluorescent probes and assay kits for detecting enzymatic activity, such as β-glucuronidase.
• Metabolite Synthesis: Acts as a purified building block for the chemical synthesis of more complex metabolite analogs for toxicological and pharmacological screening.
• Quality Control: Employed as an internal standard in quality control laboratories to ensure the accuracy and precision of analytical methods for related pharmaceutical compounds.

Basic Information

Product Name	7-Hydroxy-2H-1-Benzopyran-2-One Glucuronide Sodium Salt
CAS No.	168286-98-4
Molecular Formula	C₁₅H₁₅NaO₉
Molecular Weight	362.26 g/mol
Synonyms	7-Hydroxycoumarin glucuronide sodium salt; Umbelliferone glucuronide sodium salt; 7-Hydroxy-2-oxo-2H-chromen-7-yl β-D-glucopyranosiduronic acid sodium salt; Hymecromone metabolite sodium salt; 7-Hydroxycoumarin-β-D-glucuronide sodium; Sodium 7-((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((carboxylato)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one; 7-β-D-Glucuronosyloxycoumarin sodium salt
EINECS	Contact for details

Quality Control

Our 7-Hydroxy-2H-1-Benzopyran-2-One Glucuronide Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.