Description

Boc-L-2-Trifluoromethylphe CAS NO 167993-21-7 is a high-purity, protected amino acid derivative featuring a trifluoromethyl group on the phenylalanine side chain. This compound is a critical building block in modern pharmaceutical research and development, valued for its ability to introduce fluorine atoms to modulate the metabolic stability, lipophilicity, and bioavailability of peptide-based drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of fluorinated peptide drugs targeting metabolic diseases, oncology, and CNS disorders.
• Peptidomimetic Research: Used to incorporate the unique physicochemical properties of the trifluoromethyl group into peptide backbones to enhance binding affinity and proteolytic resistance.
• Chemical Biology Probes: Serves as a building block for creating labeled peptides and activity-based probes to study enzyme mechanisms and protein-protein interactions.
• Agrochemical Development: Employed in the research of advanced, fluorinated bioactive peptides for crop protection agents.
• Process Chemistry & Scale-up: Suitable for use in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs) under GMP guidelines.

Basic Information

Product Name	Boc-L-2-Trifluoromethylphe CAS NO 167993-21-7
CAS No.	167993-21-7
Molecular Formula	C₁₅H₁₈F₃NO₄
Molecular Weight	333.31 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid; Boc-2-CF3-Phe-OH; N-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-L-phenylalanine; Boc-L-2-(Trifluoromethyl)phenylalanine; N-Boc-2-trifluoromethyl-L-phenylalanine; tert-Butyl (2S)-2-amino-3-[2-(trifluoromethyl)phenyl]propanoate carboxylic acid; BOC-2-TFM-PHE-OH
EINECS	Contact for details

Quality Control

Our Boc-L-2-Trifluoromethylphe is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98.5% by HPLC), and related substances is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.