Description

(S)-2-(2-(Diphenylphosphino)Phenyl)-4-Isobutyl-4,5- Dihydrooxazole is a high-value chiral ligand belonging to the phosphinooxazoline (PHOX) family, essential for creating highly selective catalytic environments. Its primary value lies in enabling asymmetric synthesis, a critical process for producing enantiomerically pure pharmaceuticals and fine chemicals. This product is indispensable for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in metal-catalyzed reactions such as hydrogenations and cross-couplings.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Used in Heck reactions, Suzuki-Miyaura couplings, and other cross-coupling reactions to construct chiral centers with high enantiomeric excess.
• Pharmaceutical Intermediate Manufacturing: Critical for the production of active pharmaceutical ingredients (APIs) requiring specific chirality, such as certain antidepressants, antivirals, and cardiovascular drugs.
• Agrochemical Synthesis: Employed in the creation of chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new asymmetric transformations in academic laboratories and corporate R&D centers.
• Fine Chemical Production: Used in the synthesis of specialty flavors, fragrances, and advanced materials where optical purity is paramount.

Basic Information

Product Name	(S)-2-(2-(Diphenylphosphino)Phenyl)-4-Isobutyl-4,5- Dihydrooxazole
CAS No.	167693-62-1
Molecular Formula	C25H26NOP
Molecular Weight	387.45 g/mol
Synonyms	(S)-4-Isobutyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (S)-2-[2-(Diphenylphosphino)phenyl]-4-isobutyl-2-oxazoline; (S)-PHOX-iBu Ligand; (S)-iBu-PHOX; (S)-2-(2-(Diphenylphosphino)phenyl)-4-(2-methylpropyl)-4,5-dihydrooxazole; (S)-2-(2-Diphenylphosphinophenyl)-4-isobutyl-4,5-dihydrooxazole; L1; A chiral phosphinooxazoline ligand.
EINECS	Contact for details

Quality Control

Our production of (S)-2-(2-(Diphenylphosphino)Phenyl)-4-Isobutyl-4,5- Dihydrooxazole adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by NMR (1H, 13C, 31P), HPLC, and specific optical rotation analysis to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain efficacy. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Optical Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.