Description

3-(S)-n-Cbz-Tetrahydrofuran-3-Yl-Amine is a high-purity chiral amine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Asymmetric Catalysis: Used in the preparation of chiral ligands and organocatalysts for enantioselective transformations.
• Peptidomimetics & PROTACs: Incorporated into the backbone of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its tetrahydrofuran ring and protected amine.
• Agrochemical Synthesis: Employed in the research and development of chiral pesticides and herbicides.
• Academic & R&D: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	3-(S)-n-Cbz-Tetrahydrofuran-3-Yl-Amine
CAS No.	167640-78-0
Molecular Formula	C13H17NO3
Molecular Weight	235.28 g/mol
Synonyms	(S)-3-((Benzyloxy)carbonylamino)tetrahydrofuran; (S)-N-Cbz-3-Aminotetrahydrofuran; (S)-3-(Benzyloxycarbonylamino)tetrahydrofuran; (S)-Tetrahydrofuran-3-yl-carbamic acid benzyl ester; (3S)-3-[[(Benzyloxy)carbonyl]amino]oxolane; (S)-3-Amino-N-Cbz-tetrahydrofuran; (S)-3-(Cbz-Amino)tetrahydrofuran; Benzyl (S)-tetrahydrofuran-3-ylcarbamate
EINECS	Contact for details

Quality Control

Our 3-(S)-n-Cbz-Tetrahydrofuran-3-Yl-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.