Description

(R)-1-[(1S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldicyclohexylphosphine is a highly specialized, chiral ferrocenyl diphosphine ligand, a cornerstone in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a wide range of transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral amines, amino acids, and alcohols.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and conjugate additions to construct complex chiral molecular architectures.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides where the biological activity is often specific to one enantiomer.
• Fine Chemical and Fragrance Production: Enables the asymmetric synthesis of high-value chiral flavor and fragrance compounds.
• Academic and Industrial R&D: A vital tool for methodology development in organic synthesis and catalysis research.

Basic Information

Product Name	(R)-1-[(1S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldicyclohexylphosphine
CAS No.	167416-28-6
Molecular Formula	C36H52FeP2
Molecular Weight	602.58 g/mol
Synonyms	(R)-(S)-JOSIPHOS; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyl(dicyclohexyl)phosphine; Josiphos SL-J009-1; (R)-(S)-PPF-Cy2; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethylbis(cyclohexyl)phosphine; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphane; Ferrocenyl diphosphine ligand J009-1
EINECS	Contact for details

Quality Control

Every batch of (R)-1-[(1S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldicyclohexylphosphine is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation to ensure reproducible performance in your catalytic processes. Our quality protocols are designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.