Description

Fmoc-N'-Methyltrityl-L-Lysine CAS NO 167393-62-6 is a high-purity, orthogonally protected derivative of the essential amino acid L-lysine, specifically engineered for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity, enabling the efficient and sequential construction of complex peptides and peptidomimetics. It is an indispensable building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the controlled incorporation of lysine residues with orthogonal side-chain protection (Fmoc and Mtt groups).
• Pharmaceutical Research & Development: Synthesis of novel therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Key intermediate for creating modified peptide structures with enhanced stability, bioavailability, or receptor specificity.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Bioconjugation & Labeling: Facilitates the site-specific attachment of probes, tags, or payloads to peptides via the selectively deprotected amino group.
• Academic & Institutional Research: Fundamental reagent for studies in biochemistry, chemical biology, and medicinal chemistry.

Basic Information

Product Name	Fmoc-N'-Methyltrityl-L-Lysine
CAS No.	167393-62-6
Molecular Formula	C45H40N2O4
Molecular Weight	672.81 g/mol
Synonyms	Fmoc-Lys(Mtt)-OH; Nα-Fmoc-Nε-Mtt-L-lysine; (2S)-6-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-Lysine(Mtt)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(4-methoxytrityl)-L-lysine; Fmoc-N-ε-Mtt-L-lysine; Fmoc-Lys(Mtt)-OH (SPPS Grade)
EINECS	Contact for details

Quality Control

Our Fmoc-N'-Methyltrityl-L-Lysine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards for fine chemicals used in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.