Description

D-Isoleucine-Methyl Ester Hydrochloride is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a protected, enantiomerically pure form of D-isoleucine, which is essential for constructing complex molecules with defined stereochemistry. This compound is particularly vital for pharmaceutical research and development, serving as a key intermediate in the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptide and peptidomimetic drug development.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-isoleucine residue, which can enhance metabolic stability and alter biological activity.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies, metabolic pathway analysis, and structure-activity relationship (SAR) investigations.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in asymmetric catalytic reactions to induce stereoselectivity.
• Proteomics & Diagnostics: Can be used in the preparation of specialized reagents, labeled compounds, or probes for analytical and diagnostic applications.
• Agrochemical Development: Potential intermediate in the synthesis of chiral herbicides, fungicides, or plant growth regulators.

Basic Information

Product Name	D-Isoleucine-Methyl Ester Hydrochloride
CAS No.	167223-42-9
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	Methyl (2R,3R)-2-amino-3-methylpentanoate hydrochloride; D-Isoleucine methyl ester HCl; (2R,3R)-2-Amino-3-methylpentanoic acid methyl ester hydrochloride; Methyl D-isoleucinate hydrochloride; (R,R)-Isoleucine methyl ester hydrochloride; D-allo-Isoleucine methyl ester hydrochloride; (2R,3R)-Isoleucine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our D-Isoleucine-Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.