Description

(1R,2S)-2-Fluorocyclopropanecarboxylic Acid CAS NO 167073-08-7 is a high-value, chiral fluorinated cyclopropane building block of significant interest in modern synthetic chemistry. Its unique three-dimensional structure, featuring a fluorine atom on a strained cyclopropane ring, makes it a critical intermediate for imparting desirable metabolic stability and altering physicochemical properties in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, particularly in protease inhibitors, kinase inhibitors, and other small molecule therapeutics where the fluorocyclopropane motif can improve potency and pharmacokinetics.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the introduction of fluorine can enhance biological activity, stability, and environmental selectivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Precursor: Can be utilized in the synthesis of specialized fluorinated polymers or advanced materials with unique surface properties and chemical resistance.
• Medicinal Chemistry Probe: Employed in structure-activity relationship (SAR) studies to investigate the effects of fluorinated cyclopropane rings on binding affinity and metabolic pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	(1R,2S)-2-Fluorocyclopropanecarboxylic Acid
CAS No.	167073-08-7
Molecular Formula	C4H5FO2
Molecular Weight	104.08 g/mol
Synonyms	(1R,2S)-2-Fluorocyclopropane-1-carboxylic Acid; (-)-(1R,2S)-2-Fluorocyclopropanecarboxylic Acid; (1R-cis)-2-Fluorocyclopropanecarboxylic Acid; trans-2-Fluorocyclopropanecarboxylic Acid (enantiomer); 2-Fluorocyclopropanecarboxylic Acid, (1R,2S)-; Fluorocyclopropanecarboxylic Acid; FC-CA
EINECS	Contact for details

Quality Control

Every batch of (1R,2S)-2-Fluorocyclopropanecarboxylic Acid is produced under strict quality management protocols. We employ advanced analytical techniques, including chiral HPLC, NMR, and GC-MS, to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.