Description

Fmoc-Homocys(Trt)-Oh CAS NO 167015-23-8 is a protected amino acid derivative, specifically an Fmoc-protected homocysteine with a trityl (Trt) group on the thiol side chain. This dual protection strategy is critical for enabling the controlled, sequential synthesis of complex peptides and proteins, particularly those requiring the unique structural and functional properties of homocysteine. It is an essential building block for researchers and manufacturers in pharmaceutical development, peptide synthesis, and bioconjugation chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of homocysteine residues using Fmoc-chemistry protocols.
• Peptide Drug Discovery: Used in the research and development of novel therapeutic peptides targeting various diseases.
• Bioconjugation and Linker Chemistry: The protected thiol group allows for selective deprotection and subsequent conjugation to other molecules, such as drugs, dyes, or polymers.
• Protein Engineering: Enables the site-specific introduction of homocysteine for studying protein structure, function, and for creating engineered proteins with new properties.
• Chemical Biology Research: A valuable tool for probing biological systems and developing chemical probes.
• Synthesis of Cyclic Peptides: The thiol functionality is crucial for forming disulfide bridges or other cyclic structures in peptide design.
• Manufacture of API Intermediates: Serves as a high-purity raw material in the production of active pharmaceutical ingredients (APIs) containing modified amino acids.

Basic Information

Product Name	Fmoc-Homocys(Trt)-Oh
CAS No.	167015-23-8
Molecular Formula	C39H35NO4S
Molecular Weight	613.76 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-homocysteine; Fmoc-L-homocysteine(Trt)-OH; Fmoc-Hcy(Trt)-OH; N-α-Fmoc-S-trityl-L-homocysteine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[(triphenylmethyl)sulfanyl]butanoic acid; Fmoc-S-trityl-L-homocysteine; Fmoc-Homocysteine(Trt)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Homocys(Trt)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive applications like peptide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.