Description

Fmoc-n-(2,4,6-Trimethoxybenzyl)-Glycine is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides a critical, acid-labile protecting group for the amino side chain, enabling the synthesis of complex peptides and peptidomimetics with high precision and yield. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, combinatorial libraries, and biochemical probes. Its unique structure allows for selective deprotection under mild acidic conditions, making it indispensable for modern peptide chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating glycine residues with a protected amino side chain, essential for constructing peptides containing lysine, ornithine, or other diamino acid analogs.
• Pharmaceutical Research & Development: For the synthesis of novel therapeutic peptide candidates targeting GPCRs, enzymes, and other biological targets in drug discovery pipelines.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening to identify new bioactive compounds.
• Peptidomimetic Design: Enables the creation of modified peptide backbones and side chains with enhanced stability, bioavailability, and receptor affinity.
• Bioconjugation & Probe Synthesis: Serves as a precursor for labeling peptides with fluorophores, biotin, or other tags for diagnostic and imaging applications.
• Academic Research: A vital reagent in university and institutional labs studying protein-protein interactions, signal transduction, and structural biology.

Basic Information

Product Name	Fmoc-n-(2,4,6-Trimethoxybenzyl)-Glycine
CAS No.	166881-43-2
Molecular Formula	C28H29NO7
Molecular Weight	491.53 g/mol
Synonyms	Fmoc-N-(2,4,6-Trimethoxybenzyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(2,4,6-trimethoxybenzyl)glycine; Fmoc-Tmb-Gly-OH; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(2,4,6-trimethoxybenzyl)-; Fmoc-Nα-(2,4,6-Trimethoxybenzyl)glycine; N-Fmoc-N-(2,4,6-trimethoxybenzyl)glycine; (2,4,6-Trimethoxybenzyl)[(9H-fluoren-9-ylmethoxy)carbonyl]amino]acetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-(2,4,6-Trimethoxybenzyl)-Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and chiral analysis where applicable, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light may affect purity and performance. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.