Description

(Dab9)-Neurotensin (8-13) CAS NO 166824-25-5 is a synthetic, modified peptide fragment of the endogenous neuropeptide Neurotensin, specifically designed for enhanced stability and research utility. This compound is a critical tool for investigating neurotensin receptor (NTS1 and NTS2) signaling pathways and their roles in central nervous system function, pain modulation, and gastrointestinal physiology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, drug discovery, and peptide-based therapeutic development.

Application

• Neuroscience Research: Used as a selective ligand to study the binding, activation, and downstream effects of neurotensin receptors in the brain.
• Pharmacological Assays: Serves as a reference standard or active agent in high-throughput screening (HTS) and in vitro receptor binding studies.
• Signal Transduction Studies: Employed to elucidate intracellular pathways mediated by NTS1 and NTS2 receptors, including calcium mobilization and MAPK/ERK signaling.
• Pain and Behavioral Research: Investigated for its modulatory effects on nociception, locomotor activity, and dopamine-related behaviors in animal models.
• Drug Discovery & Development: Acts as a lead compound or template for designing novel neurotensin receptor agonists or antagonists with potential therapeutic applications.
• Biochemical Reagent: Used in the development of diagnostic assays and as a component in specialized cell culture media for receptor studies.

Basic Information

Product Name	(Dab9)-Neurotensin (8-13)
CAS No.	166824-25-5
Molecular Formula	C41H68N14O9
Molecular Weight	901.07 g/mol
Synonyms	Dab9-NT(8-13); Neurotensin (8-13), 9-(L-2,4-Diaminobutyric acid)-; Arg-Arg-Pro-Dab-Leu-Leu; H-Arg-Arg-Pro-Dab-Leu-Leu-OH; NT(8-13) analog; Neurotensin fragment 8-13 analog; L-2,4-Diaminobutyric acid9-neurotensin (8-13)
EINECS	Contact for details

Quality Control

Our (Dab9)-Neurotensin (8-13) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.