Description

(S)-Ornidazole CAS NO 166734-83-4 is the S-enantiomer of the nitroimidazole antimicrobial agent ornidazole. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its potential for enhanced pharmacological activity and reduced side-effect profiles compared to the racemic mixture. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel antiprotozoal and antibacterial therapeutics. The compound's chiral purity is a critical quality attribute for ensuring consistent and predictable biological outcomes in preclinical and clinical studies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure antimicrobial drugs.
• Pharmacological Research: Used in stereoselective metabolism and pharmacokinetic studies to understand the distinct behavior of the (S)-enantiomer.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling of ornidazole-based products.
• Preclinical Development: Integral to formulation studies and efficacy testing for new antiparasitic and antibacterial candidates targeting anaerobic bacteria and protozoa.
• Process Chemistry: Utilized in the development and optimization of asymmetric synthesis routes for nitroimidazole derivatives.

Basic Information

Product Name	(S)-Ornidazole
CAS No.	166734-83-4
Molecular Formula	C7H10ClN3O3
Molecular Weight	219.63 g/mol
Synonyms	(S)-1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole; (S)-Ornidazole; (-)-Ornidazole; Levornidazole; (S)-α-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol; (S)-1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol; (S)-2-Methyl-5-nitro-1-(3-chloro-2-hydroxypropyl)imidazole
EINECS	Contact for details

Quality Control

Our (S)-Ornidazole is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.