Description

Cyclobutanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, trans- (9Ci) CAS NO 166666-95-1 is a specialized chiral building block featuring a unique cyclobutane ring system substituted with both amino and carboxylic acid functional groups. This compound matters for its structural complexity and stereochemical purity, which are critical for synthesizing advanced pharmaceutical intermediates and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate constrained, three-dimensional frameworks into novel active compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring rigid, sterically defined scaffolds.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the cyclobutane core can impart specific biological activity and stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enhancing reaction selectivity and yield.
• Peptidomimetics Research: The constrained structure makes it valuable for designing peptide analogs (peptidomimetics) to improve metabolic stability and bioavailability in drug discovery.
• Material Science: Potential monomer or additive for creating specialized polymers with unique thermal or mechanical properties derived from the strained ring system.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways due to its functional handle for conjugation.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, trans- (9Ci)
CAS No.	166666-95-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	trans-1-Amino-2-isopropylcyclobutanecarboxylic Acid; (1R,2S)-1-Amino-2-(propan-2-yl)cyclobutanecarboxylic Acid; (1S,2R)-1-Amino-2-(propan-2-yl)cyclobutanecarboxylic Acid; 1-Amino-2-isopropylcyclobutanecarboxylic Acid, trans-; 2-Isopropyl-1-aminocyclobutanecarboxylic Acid; AICBC; Cyclobutane Amino Acid Derivative
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, trans- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.