Description

2-Fluoro-5-Methylphenylboronic Acid is a versatile and high-purity organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biphenyl or aryl-heteroaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine and methyl substituents can modulate biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Chemical Biology & Diagnostics: Useful for labeling and bioconjugation strategies, enabling the creation of probes and tools for biological research and diagnostic assays.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CROs/CMOs serving the global life sciences sector.

Basic Information

Product Name	2-Fluoro-5-Methylphenylboronic Acid
CAS No.	166328-16-1
Molecular Formula	C7H8BFO2
Molecular Weight	153.95 g/mol
Synonyms	(2-Fluoro-5-methylphenyl)boronic acid; 2-Fluoro-5-methylbenzeneboronic acid; 5-Methyl-2-fluorophenylboronic acid; Boronic acid, B-(2-fluoro-5-methylphenyl)-; 166328-16-1; 2-Fluoro-5-methylphenyl-B(OH)2; 2-Fluoro-p-tolylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Methylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is supplied with each shipment to guarantee reproducible performance and supply chain traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.