Description

Tyrosinase (206-214) (Human) is a synthetic peptide fragment corresponding to a specific region of the human tyrosinase enzyme. This high-purity peptide is a critical research tool for studying melanogenesis, autoimmune responses, and pigment cell biology. It is primarily utilized by researchers and developers in the fields of immunology, dermatology, and oncology for applications such as antibody development, epitope mapping, and biomarker discovery.

Application

• Biomedical Research: Fundamental studies on tyrosinase function, enzyme kinetics, and melanin synthesis pathways.
• Immunoassay Development: Used as a coating antigen or standard in ELISA and other immunoassays to detect anti-tyrosinase antibodies.
• Epitope Mapping & Characterization: Critical for identifying and validating the binding sites of monoclonal antibodies targeting tyrosinase.
• Autoimmune Disease Research: Investigation of vitiligo and other conditions where tyrosinase is a potential autoantigen.
• Cancer Research: Study of melanoma, as tyrosinase is a well-known tumor antigen and potential therapeutic target.
• Peptide-Based Vaccine Development: Serves as a candidate antigen for immunotherapy strategies against melanoma.
• Quality Control & Standardization: Acts as a reference standard for the quality control of diagnostic kits and reagents.

Basic Information

Product Name	Tyrosinase (206-214) (Human)
CAS No.	166188-11-0
Molecular Formula	C50H73N13O13
Molecular Weight	1048.2 g/mol
Synonyms	Human Tyrosinase Peptide (206-214); Tyr (206-214); Tyrosinase Peptide Fragment 206-214; TYR (206-214); Melanoma Antigen Peptide; HLA-A*0201-restricted Tyrosinase Epitope; YMDGTMSQV; L-Tyrosyl-L-methionyl-L-α-aspartylglycyl-L-threonyl-L-methionyl-L-seryl-L-α-glutaminyl-L-valine
EINECS	Contact for details

Quality Control

Our Tyrosinase (206-214) (Human) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the peptide lyophilized. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.