Description

Bis(3,5-Di(trifluoromethyl)phenyl)phosphine is a specialized organophosphorus ligand featuring electron-withdrawing trifluoromethyl groups. This structural feature makes it a highly valuable and selective ligand in transition metal catalysis, particularly for challenging cross-coupling reactions. It is primarily sought after by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing complex organic molecules.

Application

• Catalytic Ligand in Cross-Coupling Reactions: A key component in palladium-catalyzed Suzuki-Miyaura, Buchwald-Hartwig, and other C-C/C-N bond-forming reactions, especially for sterically hindered or deactivated substrates.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the catalytic synthesis of advanced herbicides, fungicides, and insecticides requiring specific fluorinated architectures.
• Materials Science Research: Serves as a precursor or ligand in the development of novel organometallic complexes for catalysis and electronic materials.
• Asymmetric Catalysis: Potential use in chiral catalyst systems for the synthesis of enantiomerically pure compounds.
• Academic & Industrial R&D: A critical tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	Bis(3,5-Di(trifluoromethyl)phenyl)phosphine
CAS No.	166172-69-6
Molecular Formula	C₁₆H₆F₁₂P
Molecular Weight	544.18 g/mol
Synonyms	Bis[3,5-bis(trifluoromethyl)phenyl]phosphine; Tris(3,5-bis(trifluoromethyl)phenyl)phosphine (common misnomer, verify structure); (3,5-Bis(trifluoromethyl)phenyl)phosphine (dimer); Ligand S-Phos CF3 variant; XPhos-CF3 analogue; DTFP; B3,5DTFMPP
EINECS	Contact for details

Quality Control

Every batch of Bis(3,5-Di(trifluoromethyl)phenyl)phosphine is produced and tested under strict quality management protocols to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive analytical data including HPLC purity, NMR (¹H, ¹³C, ³¹P) verification, and elemental analysis. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container tightly sealed in a cool, dry, and well-ventilated place. Separate from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
³¹P NMR Purity	≥ 95.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.