Description

(S)-1-[(R)-2-Di-(3,5-Bis(Trifluoromethyl)Phenyl)Phosphino)-Ferrocenyl]-Ethyl-Di-(3,5-Xylyl)-Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex, single-enantiomer molecules. This ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral amines, alcohols, and amino acid derivatives.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, stereocontrolled construction of chiral centers in active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and insecticides, where the biological activity is often specific to one stereoisomer.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki-Miyaura, Heck, and other cross-coupling reactions to create axially chiral biaryl compounds.
• Academic & Industrial R&D: A vital tool for methodology development in academic laboratories and process chemistry groups for route scouting and optimization.
• Fine Chemical Production: Applied in the manufacture of chiral flavors, fragrances, and advanced materials requiring high optical purity.

Basic Information

Product Name	(S)-1-[(R)-2-Di-(3,5-Bis(Trifluoromethyl)Phenyl)Phosphino)-Ferrocenyl]-Ethyl-Di-(3,5-Xylyl)-Phosphine
CAS No.	166172-66-3
Molecular Formula	C47H35F12FeP2
Molecular Weight	930.46 g/mol
Synonyms	(S,R)-Josiphos SL-J009-1; (S)-1-[(R)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos ligand SL-J009-1; (S)-1-[(R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (S)-1-[(R)-2-(Di(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; SL-J009-1; Ferrocenyl Josiphos ligand.
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and controlled under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ³¹P, ¹⁹F), and chiral analysis to guarantee chemical identity, high purity, and correct stereochemistry. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to ensure traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.