Description

(R)-1-[(S)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]Ethylbis[4-(Trifluoromethyl)Phenyl]Phosphine is a high-value, chiral ferrocenyl phosphine ligand, CAS NO 166172-60-7, prized for its exceptional ability to induce stereoselectivity in catalytic transformations. Its sophisticated structure, featuring electron-withdrawing trifluoromethyl groups, makes it a critical component for achieving high enantiomeric excess in asymmetric synthesis. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and advanced materials.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Critical for catalyzing cross-coupling, allylic substitution, and hydroformylation reactions with high stereocontrol.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Enables the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Production: Applied in the synthesis of complex, high-value flavor and fragrance compounds requiring specific chirality.
• Academic and Industrial R&D: A valuable tool for methodology development and exploring new catalytic cycles in organometallic chemistry.
• Material Science Catalysis: Investigated for use in polymerizing chiral monomers to create advanced polymeric materials with specific optical properties.

Basic Information

Item	Details
Product Name	(R)-1-[(S)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]Ethylbis[4-(Trifluoromethyl)Phenyl]Phosphine
CAS No.	166172-60-7
Molecular Formula	C45H32F12FeP2
Molecular Weight	918.51 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis[4-(trifluoromethyl)phenyl]phosphino)ferrocenyl]ethyldi(4-(trifluoromethyl)phenyl)phosphine; (R)-1-[(S)-2-(Di(4-(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi(4-(trifluoromethyl)phenyl)phosphine; Josiphos ligand SL-J009-1; (R)-1-[(S)-2-[Bis[4-(trifluoromethyl)phenyl]phosphino]ferrocen-1-yl]ethyldi[4-(trifluoromethyl)phenyl]phosphane; SL-J009-1; (R)-1-[(S)-2-(Di[4-(trifluoromethyl)phenyl]phosphino)ferrocenyl]ethyl-di[4-(trifluoromethyl)phenyl]phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure consistent high purity and performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), and metal content. Our quality systems support development and production needs in cGMP and ISO-compliant environments, ensuring reliability for your most critical asymmetric synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature in a dry environment before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.