Description

Amyloid β-Protein (1-42) (Mouse, Rat) CAS NO 166090-74-0 is a synthetic peptide fragment corresponding to the amyloid-beta protein sequence found in murine models, a critical reagent for Alzheimer's disease research. This high-purity peptide is essential for studying the mechanisms of amyloid plaque formation, neurotoxicity, and for screening potential therapeutic compounds. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurodegenerative disease models and drug discovery.

Application

• In vitro aggregation studies to model amyloid plaque formation kinetics and mechanisms.
• Neurotoxicity assays for evaluating the cytotoxic effects of amyloid-beta oligomers and fibrils on neuronal cell cultures.
• Animal model studies in transgenic mice and rats to investigate Alzheimer's disease pathology and progression.
• Therapeutic screening as a target substrate for testing inhibitors of amyloid-beta aggregation or clearance.
• Antibody development and validation for creating and testing diagnostic or therapeutic antibodies specific to murine amyloid-beta.
• Biophysical characterization using techniques like circular dichroism (CD) spectroscopy or electron microscopy to study peptide structure and morphology.
• Biomarker research to correlate amyloid-beta levels with disease states in preclinical models.

Basic Information

Product Name	Amyloid β-Protein (1-42) (Mouse, Rat)
CAS No.	166090-74-0
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol
Synonyms	Mouse/Rat Amyloid β-Protein (1-42); Aβ (1-42) (Mouse, Rat); Amyloid Beta Peptide (1-42) murine; Aβ1-42 (Mouse, Rat); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Mouse/Rat sequence); Amyloid-β (1-42) (rodent); β-Amyloid Peptide 1-42 (Murine)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-42) (Mouse, Rat) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including reverse-phase HPLC for purity verification and mass spectrometry for sequence confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to support your research compliance and reproducibility requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Solubility	Soluble in 1% acetic acid or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.