Description

Imipramine n-β-D-Glucuronide is a crucial glucuronide metabolite of the tricyclic antidepressant imipramine. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of imipramine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the Phase II conjugation pathways of imipramine, understanding its clearance and bioavailability.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring (TDM) and clinical toxicology.
• Impurity Profiling: Acts as a specified impurity standard in the quality control of imipramine active pharmaceutical ingredient (API) and finished dosage forms.
• Enzymology Research: Utilized as a substrate to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Imipramine n-β-D-Glucuronide
CAS No.	165602-94-8
Molecular Formula	C25H32N2O7
Molecular Weight	472.53 g/mol
Synonyms	Imipramine N-Glucuronide; Imipramine Glucuronide; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine N-Glucuronide; Imipramine β-D-Glucuronide; Imipramine N-β-D-Glucopyranosiduronic Acid; Imipramine N-Glucuronide Conjugate; Imipramine Metabolite Glucuronide
EINECS	Contact for details

Quality Control

Our Imipramine n-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results, ensuring traceability and compliance with research-grade standards. Specifications can be aligned with pharmacopeial guidelines for reference standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.