Description

Trimipramine n-Glucuronide is a major, pharmacologically relevant metabolite of the tricyclic antidepressant trimipramine. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK). It serves as a vital reference standard for analytical laboratories in pharmaceutical, clinical, and forensic toxicology sectors, enabling precise quantification and metabolic profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of trimipramine and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for in vitro and in vivo studies to understand the metabolic pathways, clearance, and bioavailability of trimipramine.
• Clinical Toxicology & Therapeutic Drug Monitoring (TDM): Used to calibrate assays (e.g., HPLC, LC-MS/MS) for accurate measurement of drug levels in patient plasma or serum to ensure therapeutic efficacy and safety.
• Forensic Analysis: A key analyte in forensic toxicology for the confirmation and quantification of trimipramine exposure in post-mortem or legal cases.
• Biomarker Research: Investigation of glucuronidation as a metabolic pathway and its implications for drug-drug interactions and individual metabolic phenotypes.
• Method Development & Validation: Critical for developing, optimizing, and validating new analytical methods in regulatory-compliant laboratories (GLP/GCP).

Basic Information

Product Name	Trimipramine n-Glucuronide
CAS No.	165602-84-6
Molecular Formula	C27H35N3O7
Molecular Weight	513.59 g/mol
Synonyms	Trimipramine N-Glucuronide; Trimipramine Glucuronide; 10,11-Dihydro-N,N,β-trimethyl-5H-dibenzo[b,f]azepine-5-propanamine Glucuronide; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine Glucuronide; Trimipramine N(+)-Glucuronide; Trimipramine Major Metabolite; Surmontil Metabolite
EINECS	Contact for details

Quality Control

Our Trimipramine n-Glucuronide is manufactured under strict quality control protocols suitable for analytical and research applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC, to confirm identity and ensure high purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.