Description

Clomipramine n-Glucuronide is a key metabolite of the tricyclic antidepressant clomipramine, formed via glucuronidation. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in clinical trials and regulatory submissions.

Application

• Reference Standard for Bioanalysis: Serves as a certified standard for the quantitative analysis of clomipramine and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS or HPLC.
• Pharmacokinetic & Metabolism Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of clomipramine in preclinical and clinical research.
• Doping Control & Forensic Toxicology: Used as a calibrator or control in assays designed to detect clomipramine misuse or in forensic investigations.
• Impurity Profiling: Employed in the identification and quantification of glucuronide conjugate impurities in active pharmaceutical ingredient (API) batches of clomipramine.
• Enzyme Activity Assays: Useful in vitro studies to assess the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in its formation.

Basic Information

Product Name	Clomipramine n-Glucuronide
CAS No.	165602-83-5
Molecular Formula	C25H32ClN3O6
Molecular Weight	505.99 g/mol
Synonyms	Clomipramine N-Glucuronide; Clomipramine Glucuronide; 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-aminium 1-(β-D-Glucopyranuronosyl)-1H-1,2,3-triazol-4-ide; Clomipramine Metabolite; Anafranil Glucuronide
EINECS	Contact for details

Quality Control

Our Clomipramine n-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC purity analysis, LC-MS confirmation, and residual solvent screening to ensure identity, potency, and safety. Certificates of Analysis (COA) detailing all test results and specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage, consider storage under inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.