Description

Ethyl-D-Proline CAS NO 165552-34-1 is a high-purity, non-natural amino acid derivative featuring an ethyl ester group on the proline ring. This compound is a critical chiral building block and intermediate in modern organic synthesis, prized for its role in inducing specific stereochemistry. It is primarily utilized by pharmaceutical research and development teams, as well as by fine chemical manufacturers, for the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules where the D-proline configuration is essential for activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for antiviral and cardiovascular drugs.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to incorporate D-proline motifs.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of novel protease inhibitors.
• Asymmetric Catalysis: Employed as a ligand or precursor for chiral catalysts and auxiliaries in stereoselective transformations.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme-substrate interactions and protein structure-activity relationships.
• Fine Chemical Synthesis: An important intermediate for creating complex, high-value specialty chemicals with defined stereocenters.

Basic Information

Product Name	Ethyl-D-Proline
CAS No.	165552-34-1
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	D-Proline, ethyl ester; Ethyl D-prolinate; (R)-(-)-Proline ethyl ester; (R)-1-Ethyl 2-pyrrolidinecarboxylate; Ethyl (R)-(-)-2-pyrrolidinecarboxylate; D-(-)-Proline ethyl ester; Ethyl ester of D-proline; UNII-9Q2V7I8B4F
EINECS	Contact for details

Quality Control

Our Ethyl-D-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.