Description

Butanoic Acid, 3,3-Difluoro-2-Hydroxy-, Ethyl Ester is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a difluorinated hydroxy acid ester motif that is pivotal for modulating the physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly protease inhibitors and other bioactive molecules where fluorine substitution enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-hydroxy ester group can contribute to improved efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and coatings with tailored surface properties.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for the construction of complex, fluorinated heterocycles and other sophisticated molecular scaffolds.
• Ligand and Catalyst Development: Useful for creating chiral auxiliaries or metal-chelating ligands in asymmetric catalysis.

Basic Information

Product Name	Butanoic Acid, 3,3-Difluoro-2-Hydroxy-, Ethyl Ester
CAS No.	165544-31-0
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	Ethyl 3,3-Difluoro-2-hydroxybutanoate; 2-Hydroxy-3,3-difluorobutanoic Acid Ethyl Ester; 3,3-Difluoro-2-hydroxybutyric Acid Ethyl Ester; Ethyl 3,3-Difluoro-2-hydroxybutyrate; DL-Ethyl 3,3-Difluoro-2-hydroxybutanoate; Butanoic acid, 3,3-difluoro-2-hydroxy-, ethyl ester; Ethyl 2-hydroxy-3,3-difluorobutanoate
EINECS	Contact for details

Quality Control

Our Butanoic Acid, 3,3-Difluoro-2-Hydroxy-, Ethyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to fluoride/strong alkali conditions, keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.