Description

Suc-Ala-Ala-Pro-Asp-Pna CAS NO 165174-58-3 is a synthetic peptide substrate specifically designed for biochemical research and diagnostic applications. This compound is a critical tool for the study and quantification of protease enzyme activity, particularly caspases involved in apoptosis. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors who require high-purity, well-characterized substrates for assay development and quality control.

Application

• Protease Activity Assays: Primary substrate for fluorometric or colorimetric detection of caspase-3 and related caspase enzyme activities in cell biology and apoptosis research.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic inhibitors of caspase pathways.
• Diagnostic Reagent Manufacturing: A key component in the formulation of diagnostic kits for measuring caspase activity as biomarkers for various disease states.
• Biochemical Research: Serves as a standard and control in enzymatic studies to understand protease kinetics, specificity, and mechanism of action.
• Quality Control in Biopharma: Employed in the quality control testing of biopharmaceutical products where caspase activity must be monitored or controlled.

Basic Information

Product Name	Suc-Ala-Ala-Pro-Asp-Pna
CAS No.	165174-58-3
Molecular Formula	C27H36N6O10
Molecular Weight	604.61 g/mol
Synonyms	N-Succinyl-Ala-Ala-Pro-Asp-p-nitroanilide; Suc-AAPD-pNA; Caspase-3 Substrate I; Ac-DEVD-pNA (related caspase-3 substrate); N-Succinyl-Alanyl-Alanyl-Prolyl-Aspartic acid p-nitroanilide; Suc-AAPD-pNA; AAPD-pNA; Caspase Substrate
EINECS	Contact for details

Quality Control

Every batch of Suc-Ala-Ala-Pro-Asp-Pna is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity (HPLC), identity (MS, NMR), and specific optical rotation. Our quality commitment ensures the product meets the stringent requirements for research and in-vitro diagnostic use, supporting reproducible and reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.