Description

Cyclopropanecarbonitrile, 2-Methyl-2-(1H-Pyrrol-1-Yl)-, cis- (9Ci) is a specialized organic nitrile building block featuring a unique cis-configured cyclopropane ring fused with a pyrrole moiety. This compound matters as a high-value synthetic intermediate, prized for its rigid, three-dimensional structure which is instrumental in modulating the physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material synthesis.

Application

This advanced chemical intermediate serves critical roles in sophisticated organic synthesis. Key application scenarios include:

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing complex stereochemical requirements.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the cyclopropane ring can enhance biological activity and environmental stability.
• Medicinal Chemistry & Drug Discovery: Employed as a versatile scaffold for constructing compound libraries via high-throughput screening, enabling the exploration of new chemical space for hit identification.
• Ligand and Catalyst Development: The pyrrole and nitrile functionalities make it a candidate for developing novel ligands in asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers with tailored thermal or optical properties.
• Academic & Institutional Research: Utilized in universities and R&D institutes for fundamental studies in organic synthesis methodology and reaction mechanism exploration.

Basic Information

Product Name	Cyclopropanecarbonitrile, 2-Methyl-2-(1H-Pyrrol-1-Yl)-, cis- (9Ci)
CAS No.	165059-78-9
Molecular Formula	C9H10N2
Molecular Weight	146.19 g/mol
Synonyms	cis-2-Methyl-2-(1H-pyrrol-1-yl)cyclopropanecarbonitrile; (1R,2S)-rel-2-Methyl-2-(1H-pyrrol-1-yl)cyclopropanecarbonitrile; 2-Methyl-2-(pyrrol-1-yl)cyclopropanecarbonitrile (cis-); 1-Cyano-2-methyl-2-(1-pyrrolyl)cyclopropane (cis-); Cyclopropanecarbonitrile, 2-methyl-2-(1H-pyrrol-1-yl)-, (1R,2S)-rel-; 165059-78-9; cis-Isomer of 2-Methyl-2-(pyrrol-1-yl)cyclopropanecarbonitrile.
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonitrile, 2-Methyl-2-(1H-Pyrrol-1-Yl)-, cis- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity assessment and structural confirmation, to ensure consistency and reliability for your sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The container should be kept tightly sealed when not in use to prevent moisture absorption or contamination. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.