Description

(4R)-4-(1,1-Dimethylethyl)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-Oxazole is a chiral, P,N-bidentate ligand widely used in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates in fine chemical synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand for asymmetric hydrogenation of olefins, ketones, and imines.
• Catalyst component in asymmetric C-C bond-forming reactions such as cross-coupling and allylic substitution.
• Key reagent in the synthesis of enantiomerically pure pharmaceutical intermediates and active ingredients.
• Use in the development of novel agrochemicals requiring specific stereochemistry for activity.
• Research tool in academic and industrial laboratories for methodology development in organic synthesis.
• Potential application in the synthesis of specialty polymers and advanced materials with chiral centers.

Basic Information

Product Name	(4R)-4-(1,1-Dimethylethyl)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-Oxazole
CAS No.	164858-79-1
Molecular Formula	C25H26NOP
Molecular Weight	387.45 g/mol
Synonyms	(R)-tert-ButylPHOX; (R)-4-tert-Butyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole; (R)-t-Bu-PHOX; (4R)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline; (R)-2-[2-(Diphenylphosphino)phenyl]-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; PHOX Ligand (tert-Butyl variant); P,N-Ligand
EINECS	Contact for details

Quality Control

Our production of (4R)-4-(1,1-Dimethylethyl)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-Oxazole adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by NMR, HPLC, and chiral analysis to confirm identity, assay, and enantiomeric excess. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.