Description

(R)-(+)-2-[2-(Diphenylphosphino)Phenyl]-4-(1-Methylethyl)-4,5-Dihydrooxazole is a high-value, chiral phosphine-oxazoline ligand, a key component in asymmetric catalysis. This compound matters because it enables highly selective transformations, crucial for synthesizing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing single-isomer active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in palladium-catalyzed cross-coupling and allylic substitution reactions to construct chiral carbon frameworks with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of chiral intermediates for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Methodology Development in Academia & R&D: A standard tool in academic and industrial laboratories for developing new catalytic asymmetric synthetic methodologies.
• Fine Chemical Production: Applied in the manufacture of specialty flavors, fragrances, and advanced materials requiring precise chiral induction.

Basic Information

Product Name	(R)-(+)-2-[2-(Diphenylphosphino)Phenyl]-4-(1-Methylethyl)-4,5-Dihydrooxazole
CAS No.	164858-78-0
Molecular Formula	C24H24NOP
Molecular Weight	373.43 g/mol
Synonyms	(R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydrooxazole; (R)-4-Isopropyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (R)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline; (R)-iPr-PHOX; PHOX Ligand (iPr variant); (R)-(+)-PHOX; (R)-2-[2-(Diphenylphosphino)phenyl]-4-(1-methylethyl)-2-oxazoline; L1 (common ligand designation in catalysis literature)
EINECS	Contact for details

Quality Control

Our (R)-(+)-PHOX ligand is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR (1H, 13C, 31P), HPLC for chiral purity, and elemental analysis. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically >98%), and enantiomeric excess (ee >99%). Our quality system supports cGMP and ISO 9001 standards for advanced chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient conditions should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.