Description

1Alpha,5Alpha,6Beta-3-Benzyl-6-Dibenzylamino-3-Aza-Bicyclo[3.1.0]Hexane-6-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex, rigid bicyclic structure. This compound is of significant value for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the synthesis of complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing novel chemical libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex target molecules in GMP and non-GMP environments.
• Academic Research: Utilized in universities and research institutes for studying synthetic methodologies, reaction mechanisms, and the properties of strained bicyclic systems.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for use in custom synthesis projects for client APIs.

Basic Information

Product Name	1Alpha,5Alpha,6Beta-3-Benzyl-6-Dibenzylamino-3-Aza-Bicyclo[3.1.0]Hexane-6-Carbonitrile
CAS No.	164799-11-5
Molecular Formula	C27H27N3
Molecular Weight	393.53 g/mol
Synonyms	3-Benzyl-6-(dibenzylamino)-3-azabicyclo[3.1.0]hexane-6-carbonitrile; 3-Azabicyclo[3.1.0]hexane-6-carbonitrile, 3-benzyl-6-(dibenzylamino)-; 1α,5α,6β-3-Benzyl-6-dibenzylamino-3-aza-bicyclo[3.1.0]hexane-6-carbonitrile; Bicyclo[3.1.0]hexane-6-carbonitrile, 3-benzyl-6-(dibenzylamino)-3-aza-; (1α,5α,6β)-3-Benzyl-6-(dibenzylamino)-3-azabicyclo[3.1.0]hexane-6-carbonitrile
EINECS	Contact for details

Quality Control

Our 1Alpha,5Alpha,6Beta-3-Benzyl-6-Dibenzylamino-3-Aza-Bicyclo[3.1.0]Hexane-6-Carbonitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and available upon request. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.