Description

Ibufenac Acyl-β-D-Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) Ibufenac, formed via glucuronidation in the liver. This compound is of significant importance in pharmaceutical research and development for studying drug metabolism, pharmacokinetics, and the potential bioactivity of drug conjugates. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical and biotechnology industries for analytical reference standards and metabolic pathway investigations.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of Ibufenac metabolites in biological matrices during drug development and bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used in in vitro and in vivo studies to elucidate the metabolic fate, clearance pathways, and potential enterohepatic recirculation of Ibufenac.
• Analytical Method Development: Critical for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic profiling.
• Toxicology and Safety Assessment: Employed to investigate the role of acyl glucuronides in potential drug-induced toxicity, including protein adduct formation.
• Biochemical Research: Used as a substrate or inhibitor in studies focusing on UDP-glucuronosyltransferase (UGT) enzyme activity and specificity.

Basic Information

Product Name	Ibufenac Acyl-β-D-Glucuronide
CAS No.	164669-89-0
Molecular Formula	C20H26O9
Molecular Weight	410.42 g/mol
Synonyms	Ibufenac Acyl Glucuronide; Ibufenac 1-O-Acyl-β-D-Glucuronide; 4-Isobutylphenylacetic Acid Acyl-β-D-Glucuronide; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[(4-isobutylphenyl)acetoxy]oxane-2-carboxylic Acid; Ibufenac β-D-Glucuronide Ester; p-Isobutylhydratropic Acid Acyl Glucuronide; Ibufenac Metabolite Standard
EINECS	Contact for details

Quality Control

Our Ibufenac Acyl-β-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, purity, and specified impurities. We support compliance with relevant guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.