Description

4,4,4-Trifluorobutan-1-Ol Methanesulfanate is a specialized fluorinated organic building block and methanesulfonate ester. This compound is valued for its role as a key intermediate in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, where the introduction of the trifluoromethyl group and the reactive methanesulfonate leaving group are critical for structure-activity relationship studies and lead optimization.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a trifluoromethylated butyl chain.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where fluorination enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and advanced materials with unique surface properties.
• Liquid Crystal & OLED Research: Employed in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: The methanesulfonate group acts as an effective leaving group in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings.
• Protease Inhibitor Development: Used as a key fragment in the design and synthesis of protease inhibitor candidates for therapeutic applications.

Basic Information

Product Name	4,4,4-Trifluorobutan-1-Ol Methanesulfanate
CAS No.	164523-19-7
Molecular Formula	C5H9F3O3S
Molecular Weight	206.19 g/mol
Synonyms	4,4,4-Trifluorobutyl methanesulfonate; 1-Butanol, 4,4,4-trifluoro-, methanesulfonate; 4,4,4-Trifluorobutyl mesylate; 4,4,4-Trifluoro-1-butanol methanesulfonate; 4,4,4-Trifluorobutane-1-ol mesylate; Mesylic acid, 4,4,4-trifluorobutyl ester; 164523-19-7; 4,4,4-Trifluorobutyl methanesulphonate
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobutan-1-Ol Methanesulfanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.