Description

(S)-Tetrahydrofuran-2-Carbonitrile is a high-value, chiral building block and intermediate in organic synthesis. Its significance lies in its stereochemically defined tetrahydrofuran core, which is a privileged scaffold found in numerous biologically active molecules and pharmaceuticals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce chiral complexity into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing tetrahydrofuran or pyrrolidine motifs.
• Agrochemical Synthesis: Used in the research and production of chiral herbicides, fungicides, and insecticides where specific stereochemistry is crucial for activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Natural Product Synthesis: An important building block for the total synthesis of complex natural products containing oxygenated heterocycles.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(S)-Tetrahydrofuran-2-Carbonitrile
CAS No.	164472-78-0
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(S)-2-Cyanotetrahydrofuran; (S)-Tetrahydro-2-furancarbonitrile; (S)-Tetrahydrofuran-2-carbonitrile; (2S)-Oxolane-2-carbonitrile; (S)-2-Tetrahydrofurancarbonitrile; (S)-THF-2-CN; (S)-2-Cyanooxolane
EINECS	Contact for details

Quality Control

Our (S)-Tetrahydrofuran-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/Chiral GC), to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) specifying identity, purity, enantiomeric excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.