Description

(1R,2S)-Fluorocyclopropanamine Para Toluenesulfonate is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its unique fluorinated cyclopropane structure, which is critical for modulating the biological activity, metabolic stability, and physicochemical properties of advanced drug candidates. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, antiviral agents, and enzyme inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the fluorocyclopropane moiety can enhance bioavailability and environmental stability.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral amine source in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Fluorine Chemistry: An important reagent for introducing fluorine atoms in a stereocontrolled manner, a common strategy in modern drug design.
• Process Chemistry: Used in the scale-up and route development for the commercial manufacturing of chiral drugs.

Basic Information

Product Name	(1R,2S)-Fluorocyclopropanamine Para Toluenesulfonate
CAS No.	164062-84-4
Molecular Formula	C10H14FNO3S
Molecular Weight	247.29 g/mol
Synonyms	(1R,2S)-1-Amino-2-fluorocyclopropane p-toluenesulfonate; (1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate; (1R,2S)-1-Fluoro-2-aminocyclopropane Tosylate; trans-(1R,2S)-Fluorocyclopropanamine Tosylate; Fluorocyclopropanamine p-Toluenesulfonate Salt; (1R,2S)-F-CPA Tosylate; (1R,2S)-1-Fluoro-2-cyclopropanamine Tosic Acid Salt
EINECS	Contact for details

Quality Control

Our (1R,2S)-Fluorocyclopropanamine Para Toluenesulfonate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.