Description

3-(3,5-Difluoro-Phenyl)-Propionic Acid Ethyl Ester is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and a versatile ester functional group, enabling precise modifications to molecular properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides where fluorine substitution enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated aromatic cores in electronic and display chemicals.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers to alter surface energy and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new fluorination strategies and creating specialized chemical libraries.

Basic Information

Product Name	3-(3,5-Difluoro-Phenyl)-Propionic Acid Ethyl Ester
CAS No.	163978-51-6
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	Ethyl 3-(3,5-Difluorophenyl)propanoate; 3,5-Difluorophenylpropionic Acid Ethyl Ester; 3-(3,5-Difluorophenyl)propanoic Acid Ethyl Ester; Ethyl 3,5-Difluorohydrocinnamate; 3,5-Difluoro-β-phenylpropionic Acid Ethyl Ester; NSC 405124; AI3-52062
EINECS	Contact for details

Quality Control

Every batch of 3-(3,5-Difluorophenyl)-Propionic Acid Ethyl Ester is produced under strict quality management protocols. We ensure compliance with cGMP standards where applicable, and our in-house analytical lab verifies identity, purity, and consistency through advanced techniques like GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.