Description

(R)-(-)-Nbd-Py-Ncs CAS NO 163927-29-5 is a high-purity, chiral chemical intermediate featuring a reactive isothiocyanate (NCS) group and a nitrobenzoxadiazole (NBD) fluorophore. This compound matters for researchers and manufacturers requiring precise, fluorescent labeling of biomolecules, particularly for creating targeted diagnostic probes and research tools. It is primarily needed by the pharmaceutical, biotechnology, and life science research industries for applications in assay development, bio-conjugation, and fluorescence-based imaging.

Application

• Fluorescent Probe Synthesis: A key building block for creating sensitive fluorescent labels and tags for biological detection.
• Bioconjugation Reagent: Used to covalently attach fluorescent markers to proteins, antibodies, peptides, and other biomolecules via its reactive isothiocyanate group.
• Diagnostic Assay Development: Essential in the research and production of diagnostic kits for clinical testing and biomedical research.
• Cellular Imaging Studies: Enables the visualization and tracking of cellular processes and molecular targets in live or fixed cells.
• High-Throughput Screening (HTS): Used to develop fluorescent assays for drug discovery and pharmacological research.
• Sensor Fabrication: Incorporated into chemical sensors and biosensors for environmental monitoring or analytical chemistry.

Basic Information

Item	Detail
Product Name	(R)-(-)-Nbd-Py-Ncs
CAS No.	163927-29-5
Molecular Formula	C₁₉H₁₃N₅O₄S
Molecular Weight	407.40 g/mol
Synonyms	(R)-4-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-2-(isothiocyanatomethyl)pyrrolidine; (R)-NBD-Py-NCS; (R)-NBD-APy-NCS; (R)-(-)-NBD-Aminopyrrolidine-NCS; 4-((R)-2-(Isothiocyanatomethyl)pyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole; NBD Fluorophore Pyrrolidine Isothiocyanate (R-enantiomer); NBD-PYR-NCS (R); Fluorescent Isothiocyanate Labeling Reagent (R)
EINECS	Contact for details

Quality Control

Our (R)-(-)-Nbd-Py-Ncs is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.