Description

Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse is a synthetic peptide sequence corresponding to amino acids 35-55 of the myelin oligodendrocyte glycoprotein (MOG). This compound is a critical research tool for studying the pathogenesis of autoimmune demyelinating diseases, particularly experimental autoimmune encephalomyelitis (EAE), a widely used animal model for multiple sclerosis. It is essential for immunologists and neuroscientists in academic, pharmaceutical, and biotechnology sectors focused on neuroinflammation, autoimmune disorder mechanisms, and therapeutic development.

Application

• Induction of Experimental Autoimmune Encephalomyelitis (EAE): Primary antigen for inducing a robust and reproducible EAE model in susceptible rodent strains (e.g., C57BL/6 mice).
• T-Cell Epitope Mapping & Immunology Research: Used to study antigen-specific T-cell activation, proliferation, and cytokine profiles in neuroinflammatory contexts.
• Multiple Sclerosis (MS) Research: Fundamental for investigating the role of MOG-specific immune responses in demyelination and MS pathology.
• Vaccine & Therapeutic Evaluation: Serves as a target antigen for screening and validating potential immunotherapies, tolerogenic vaccines, or drug candidates aimed at modulating autoimmune responses.
• Antibody Production & Characterization: Used as an immunogen to generate monoclonal or polyclonal antibodies specific to the MOG35-55 epitope for diagnostic and research applications.
• Blood-Brain Barrier (BBB) Studies: Employed in research models to examine the interaction between activated immune cells and the BBB in autoimmune neuroinflammation.

Basic Information

Product Name	Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse
CAS No.	163913-87-9
Molecular Formula	C98H155N29O31
Molecular Weight	2247.5 g/mol
Synonyms	MOG Peptide 35-55; MOG35-55; MOG (35-55); Myelin Oligodendrocyte Glycoprotein (35-55); MOG p35-55; MOG Peptide Fragment; Encephalitogenic MOG Peptide; MOG Antigen; MEVGWYRSPFSRVVHLYRNGK
EINECS	Contact for details

Quality Control

Our Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 is manufactured under stringent conditions to ensure the highest standards of purity and biological activity for research use. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	MEVGWYRSPFSRVVHLYRNGK
Single-Letter Code	M-E-V-G-W-Y-R-S-P-F-S-R-V-V-H-L-Y-R-N-G-K
Molecular Weight	2247.5 g/mol (theoretical average)
Solubility	Soluble in water or dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.