Description

2-Pyrrolidinone,5-(3-Methyl-5-Isoxazolyl)-,(S)-(9Ci) is a high-purity chiral intermediate of significant interest in advanced organic synthesis. Its value lies in its role as a key building block for the development of novel, biologically active molecules, particularly within the pharmaceutical sector. This compound is essential for researchers and manufacturers in medicinal chemistry and fine chemical production who require a reliable source of a structurally defined, enantiomerically pure heterocyclic scaffold.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce complex heterocyclic motifs with defined stereochemistry.
• Fine Chemical Production: Acts as a precursor in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value compounds requiring the (S)-configured pyrrolidinone core.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for enantioselective transformations.

Basic Information

Product Name	2-Pyrrolidinone,5-(3-Methyl-5-Isoxazolyl)-,(S)-(9Ci)
CAS No.	163849-08-9
Molecular Formula	C8H10N2O2
Molecular Weight	166.18 g/mol
Synonyms	(S)-5-(3-Methylisoxazol-5-yl)pyrrolidin-2-one; (5S)-5-(3-Methyl-1,2-oxazol-5-yl)-2-pyrrolidinone; (S)-5-(3-Methyl-5-isoxazolyl)-2-pyrrolidinone; (S)-5-(3-Methylisoxazol-5-yl)-2-pyrrolidinone; 2-Pyrrolidinone, 5-(3-methyl-5-isoxazolyl)-, (S)-; (S)-5-(3-Methyl-5-isoxazolyl)pyrrolidin-2-one; (S)-5-(3-Methylisoxazol-5-yl)-2-pyrrolidone; (S)-5-(3-Methyl-5-isoxazolyl)-2-pyrrolidone
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinone,5-(3-Methyl-5-Isoxazolyl)-,(S)-(9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and impurity profiling. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.