Description

Dmt-2′o-Moe-Rmec(Bz) Phosphoramidite is a high-purity, protected phosphoramidite monomer essential for the automated solid-phase synthesis of oligonucleotides. This compound is a critical building block for creating modified RNA strands with enhanced stability and specificity, which is fundamental for advanced therapeutic and diagnostic applications. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Oligonucleotide Synthesis: A key monomer for the automated synthesis of 2'-O-methoxyethyl (2'-MOE) modified RNA oligonucleotides.
• Therapeutic Development: Critical for manufacturing antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) for gene silencing therapies.
• Diagnostic Probes: Used in the production of high-specificity probes for molecular diagnostics and genomic research.
• Research & Development: Enables academic and industrial research into RNA structure, function, and novel nucleic acid chemistries.
• Bioconjugation: Serves as an intermediate for creating labeled or conjugated oligonucleotides for targeted delivery or imaging.

Basic Information

Product Name	Dmt-2′o-Moe-Rmec(Bz) Phosphoramidite
CAS No.	163759-94-2
Molecular Formula	C46H55N4O9P
Molecular Weight	839.93 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N4-benzoyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-MOE-C(Bz) Phosphoramidite; 5'-DMT-2'-O-MOE-N4-Bz-Cytidine CE Phosphoramidite; 2'-O-(2-Methoxyethyl)cytidine phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)cytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 2'-MOE-C(Bz) CE Phosphoramidite; 2'-O-Methoxyethyl Cytidine Phosphoramidite (Bz protected)
EINECS	Contact for details

Quality Control

Our Dmt-2′o-Moe-Rmec(Bz) Phosphoramidite is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is rigorously tested via HPLC, 31P NMR, and 1H NMR to confirm identity, purity, and stability. Certificates of Analysis (COA) with full analytical data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.