Description

H-β-Chloro-Ala-Nhoh is a specialized amino acid derivative with a chlorinated β-carbon and a hydroxamic acid functional group, identified by CAS number 163682-35-7. This unique molecular architecture makes it a valuable building block and intermediate for synthesizing complex bioactive molecules and novel chemical entities. It is primarily required by pharmaceutical research organizations and fine chemical manufacturers developing protease inhibitors, metalloenzyme modulators, and advanced peptide mimetics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting enzymatic pathways.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of metalloproteases and other hydrolytic enzymes due to its hydroxamic acid moiety.
• Chemical Biology Research: Used as a tool compound or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance stability, bioavailability, or biological activity.
• Chelating Agent Precursor: Utilized in the development of specialized chelators for metal ions in catalytic or diagnostic applications.
• Fine Chemical Production: Employed in multi-step organic synthesis for creating complex, high-value specialty chemicals.

Basic Information

Product Name	H-β-Chloro-Ala-Nhoh
CAS No.	163682-35-7
Molecular Formula	C₃H₇ClN₂O₂
Molecular Weight	138.55 g/mol
Synonyms	3-Chloro-2-(hydroxyamino)propanoic acid; 3-Chloroalanine hydroxamic acid; β-Chloroalanine hydroxamic acid; H-β-Cl-Ala-NHOH; 2-Amino-3-chloropropanehydroxamic acid; (2R)-2-Amino-3-chloropropanehydroxamic acid (for enantiomer); L-β-Chloroalanine hydroxamic acid
EINECS	Contact for details

Quality Control

Our H-β-Chloro-Ala-Nhoh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing batch-specific data is available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.